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Plutarch was of the view that he became disabled by means of an attempt on his life by Philip II's wife, Queen Olympias, who wanted to eliminate a possible rival to her son, Alexander, through the employment of pharmaka (drugs/spells); however, most modern authorities doubt the truth of this claim., both to protect his life and to prevent his use as a pawn in any prospective challenge for the throne.
After Alexander's death in Babylon in 323 BC, the Macedonian army in Asia proclaimed Arrhidaeus as king; however, he served merely as a figurehead and as the pawn of a series of powerful generals.
Even though Arrhidaeus and Alexander were about the same age, Arrhidaeus appears never to have been a danger as an alternative choice for Alexander's succession to Philip II; nevertheless, when the Persian satrap of Caria, Pixodarus, proposed his daughter in marriage to Philip, the king declined, offering his son Arrhidaeus as husband instead, and Alexander thought it prudent to block the dynastic union (which might have produced a possible future heir to Philip's domain before Alexander himself did), resulting in considerable irritation on the part of his father (337 BC).
Arrhidaeus' whereabouts during the reign of his brother Alexander are unclear from the extant sources; what is certain is that no civil or military command was given to him in those thirteen years (336–323 BC).
Eumenes later replaced it with a new one, telling him to bury the chariot.
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He was in Babylon at the time of Alexander's death on 10 June 323 BC. Arrhidaeus was the most obvious candidate, but he was mentally unfit to rule.
But individual circumstances and events at this time were subject to rapid change.
He appears as one of the main characters in the novel Funeral Games by Mary Renault.
In Renault's version, the villainous Cassander slows down his advance on Macedonia to give Olympias enough time to kill Arrhidaeus and Eurydice.
From that moment on, Philip Arrhidaeus was to be under the sway of his bride, a proud and determined woman bent on substantiating her husband's power. The regent died of natural causes the following year, nominating as his successor not his son Cassander, but his friend and lieutenant, Polyperchon.
Cassander's refusal to accept his father's decision sparked the Second War of the Diadochi, in which Eurydice saw once again a chance to free Philip from the control of the regent.